The Chromatin Digest

Tag: enhancers

  • Decoding the molecular wiring underlying early development

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    Isabella
    in ,

    Schematic of a poised enhancer, its associated modifications, and how it contacts its target gene. Designed in Biorender by me, 2023 (Figure 1B, BSc thesis) In the earliest stages of human development, it’s vital that genes are expressed at very specific times and places. If this goes wrong, developmental defects can arise. Enhancer regions, particularly…

  • A tale of two sequences

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    Isabella
    in

    Lego bricks join up easily, with each part having a distinct function. Photo by Arto Alanenpää on Wikimedia Commons, under CC BY-SA 4.0. Biology never makes things easy for us. It’s tempting to think of the genome as a well-oiled machine, with separate regions that join neatly together like Lego bricks to perform an overall…